Systematic Literature Review
What is the aim of the systematic literature review?
The nAMD Barometer Leadership Coalition conducted a systematic literature review of factors affecting non-adherence (NA) to, and non-persistence (NP) with, intravitreal anti-VEGF therapy for nAMD, with the aims of:
- Identifying risk factors for non-adherence and non-persistence
- Evaluating existing strategies to improve adherence or persistence
- Investigating rates of non-adherence to and non-persistence with anti-VEGF therapy for nAMD in real-world practice
Definitions for NA/NP are not standardised in nAMD
Standardised definitions are needed to accurately investigate levels of NA/NP in the real-world
Few studies have investigated the reasons for NA/NP
There is a need to better understand risk factors associated with NA/NP
NA/NP predominantly occurs within 12–24 months
Represents a key window for patient education intervention
Older age and lower income are common characteristics associated with NA/NP
Triaging patients based on known risk factors for interventions should be explored
Perception of stable disease is a key reason for NA/NP
Represents an opportunity to improve patient education around the purpose of treatment to set appropriate expectations
